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Solutions for Amino Acids, Peptides, and Proteins
deprotect the N-terminus
add the next amino acid
activate the C-terminus
add the next amino acid
activate the
C-terminus
protect the N-terminus of the first amino acid
H2, Pd
phenylalanine
44
+
leucine
(a)
alanine
Cl C
O
OEt
C O
O
CH
CH2CHMe2
NH CZ
CH2CHMe2
CH2CHMe2
CH2CHMe2
CH2CHMe2
O
CH
CH3
Z NH NHCH C
O
C
O
OH
C OEt
O
Cl
C O
O
CHC NH
O
CHNHZ
CH3
C
O
OEt
OEt
H2N CH
CH2Ph
COOH
CH COOH
CH2Ph
NHCH
CH3
Z NH NHCH C
O
C
O
C NH
O
CHC NH
O
CHH2N
CH3
CH
CH2Ph
COOH
PhCH2OC Cl
O
CH COOH
CH2CHMe2
H2N NH CH C
CH2CHMe2
OH
O
Z
CH COOH
CH3
H2N
649