Lista de doenças autoimunes

Prévia do material em texto

LISTA COMPLETA DE DOENÇAS
	LISTA DE DOENÇAS AUTOIMUNES POR ESPECIALIDADES MÉDICAS
	REUMATO
		Doenças difusas do tecido conjuntivo, incluindo vasculites sistêmicas
		Síndrome anti-fosfolípide
			Síndrome HELLP (SAF, trombocitopenia, hemólise, elevação de enzimas hepáticas)
		Doença de Behçet
		Artrite reumatóide
		Artrite reumatóide juvenil
		Polimialgia reumática
		Poliarterite nodosa
		Arterite de células gigantes (arterite temporal)
		Arterite de Takayasu
		Granulomatose com poliangeite (Wegener)
		Granulomatose com poliangeite e eosinofilia (Churg-Strauss)
		Síndrome de Sjögren
		Polidermatomiosite
		Miosite por corpúsculos de inclusão
		Miosite associada a vastatinas
		Esclerodermia
		Espondiloartrites
		Artrite psoriásica
		Reumatismo palindrômico
		Fasciite eosinofílica
		Imunodeficiência autoimune
		Crioglobulinemia essencial mista
		Rayanud
		Artrites reativas
		Policondrite recidivante
		Chronic recurrent multifocal ostomyelitis (CRMO)
		Autoimmune angioedema
		Henoch-Schonlein purpura
		Leukocytoclastic vasculitis
		Cogans syndrome
		Kawasaki syndrome
		Lupus eritematoso sistêmico
	HEMATO
		Anemias autoimunes
			Anemia aplástica autoimune
			Anemia hemolítica
			Anemia perniciosa
		Púrpura trombocitopênica autoimune
		Síndrome de Evans (anemia hemolítica Coombs+, púrpura trombocitopênica autoimune, com neutropenia autoimune em 15% dos casos)
		Ooforite utoimune
		Mielofibrose autoimune
	GINECO
		Mastopatia granulomatosa autoimune
		Endometriose
	ENDOCRINO
		Diabetes mellitus tipo I
		Addison
		Hashimoto
		Graves
		Type I, II, & III autoimmune polyglandular syndromes
	GASTRO & HEPATOLOGIA
		Hepatite autoimune tipo 1
		Hepatite autoimune tipo 2
		Colangite biliar primária (ex-cirrose)
		Colangite autoimune
		Colangite esclerosante primária
		Doença celíaca
		Esofagite eosinofílica
		Pancreatite autoimune
		Doença de Crohn
		Retocolite ulcerativa
	NEFRO
		Glomerulonefrite
		Goodpasture
		Nefropatia por IgA
		Interstitial cystitis
		Microscopic polyangiitis
		Amyloidosis
		Anti-GBM/Anti-TBM nephritis
		Paroxysmal nocturnal hemoglobinuria (PNH)
	NEUROLOGIA
		Guillain-Barré
		Neuropatias desmielinizantes
Dr. Carlos A von Muhlen: tember 2013, Vol. 34, No. 9 p. 453.
Glycolipid antigens and autoantibodies
in autoimmune neuropathies
Hugh J. Willison and Carl S. Goodyear
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow,
Glasgow G12 8TA, UK
Autoantibodies to glycans present on glycolipids mediate the postinfectious paralytic disease, Guillain–Barre´
syndrome (GBS). These glycans are also found on lipooligosaccharides (LOSs) ofGBS-inducingmicrobes, suggesting molecular mimicry as a mechanism for disease
induction.HowBlymphocytetolerancetoself-glycans is
regulated during the initiation phase of the disease is
currently under investigation. The discovery of antiglycolipid antibodies that bind to heteromeric glycolipid
complexes has generated new insights in this field.
Heteromeric complexes are structurally distinct glycolipids thatinteractto form newmolecular shapes capable
of either enhancing or attenuating recognition by autoantibodies. Although the principles emerging from this
phenomenon have a substantial impact on diagnostics
methods,they also raise intriguing questions aboutthe
diversity of innate antibody repertoires, mechanisms of
tolerance, and autoantibody targeting of neural membranes.
		Miastenia gravis
		Esclerose múltipla
		Encefalomielite experimental alérgica
		Doença de Devic (neuromielite óptica)
		Encefalomielite perivenosa
		Narcolepsy
		Acute Disseminated Encephalomyelitis (ADEM)
		Acute necrotizing hemorrhagic leukoencephalitis
		PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus)
		Paraneoplastic cerebellar degeneration
		Transverse myelitis
		Chronic inflammatory demyelinating polyneuropathy (CIDP)
		Lambert-Eaton syndrome
		Encefalite Límbica Autoimune
			Paraneoplásica
				Hu
				CV2/CRMP5
				Ma2
				anfifisina
			Autoimune
				VGKC (voltage-gated potassium channel)
				receptores de glutamato tipo NMDA (células HEK-293 transfectadas com receptor NMDA)
				receptores de glutamato tipo AMPA
				receptores de glutamato tipo GABA
		ADEM
Dr. Carlos A. von Muhlen: Dr. Carlos A. von Muhlen:
Intern Med. 2016;55(21):3181-3184. Epub 2016 Nov 1.
Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.
Sekiguchi K1, Yasui N, Kowa H, Kanda F, Toda T.
Author information
Abstract
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.
		Astrocitopatia autoimmune
Dr. Carlos A. von Muhlen: Dr. Carlos A. von Muhlen:
Ann Neurol. 2017 Jan 24. doi: 10.1002/ana.24881. [Epub ahead of print]
GFAP-IgG as Biomarker of Autoimmune Astrocytopathy: Analysis of 102 Patients.
Flanagan EP1,2, Hinson SR2, Lennon VA1,2,3, Fang B2, Aksamit AJ1, Morris PP4, Basal E2, Honorat JA2, Alfugham NB1, Linnoila JJ1, Weinshenker BG1,2, Pittock S1,2, McKeon A1,2.
Author information
Abstract
Objective A novel autoimmune CNS disorder with glial fibrillary acidic protein (GFAP)-IgG as biomarker was recently characterized. Here, 102 patients with GFAP-IgG positivity are described. Methods The 102 included patients had: 1) serum, CSF or both that yielded a characteristic astrocytic pattern of mouse tissue immunostaining; 2) confirmation of IgG reactive with specific GFAP isoforms (α, ε, or κ) by cell-based assays, and 3) clinical data available. Control specimens (865) were evaluated by tissue (542) and cell-based (323) assays. Results Median symptom-onset age was 44 years (range, 8-103) and 54% were women. The predominant phenotype (83 patients; 81%) was inflammation of meninges, brain or spinal cord, or all 3 (meningoencephalomyelitis). Among patients, highest specificity for those phenotypes was observed for CSF testing (94%), and highest sensitivity was for the GFAPα isoform (100%). Rare GFAP-IgG positivity was encountered in serum controls by tissue-based assay (0.5%) or cell-based assay (1.5%), and in CSF controls by cell-based assay (0.9%). Among patients, striking perivascular radial enhancement was found on brain MRI in 53%. Though cases frequently mimicked vasculitis, angiography was uniformly negative, and spinal imaging frequently demonstrated longitudinally-extensive myelitic lesions. Diverse neoplasms encountered were found prospectively in 22%. Ovarian teratoma was most common and was predicted best when both NMDA-R-IgG and AQP4-IgG coexisted (71%). Six patients with prolonged follow-up had brisk corticosteroid response, but required additional immune-suppression to overcome steroid-dependency. Interpretation GFAPα-IgG when detected in CSF, is highly specific for an immunotherapy-responsive autoimmune CNS disorder, sometimes with paraneoplastic cause.
	OTORRINO
		Surdez neurosensorial autoimune
		Castleman disease
		Meniere’s disease
	DERMATO
		Alopecia areata
		Dermatite herpetiforme
		Eritema nodoso
		Lichen planus
		Lichen sclerosus
		Linear IgA disease (LAD)
		Lupus discóide
		Pênfigo
		Penfigóide bolhoso
		Psoríase
		Pyoderma gangrenosum
		Urticária autoimune
		Vesiculobullous dermatosis
		Vitiligo
	PNEUMO
		Sarcoidose
		Alveolite fibrosante
		Proteinose alveolar autoimune
	CARDIO
		Pericardite autoimune
		Disautonomia autoimune
		Miocardite de células gigantes
		Miocardite autoimune
		Cardiomiopatia
		Hiperlipidemia autoimuneSíndrome pós-pericardiotomia
		Postmyocardial infarction syndrome
		Autoimmune dysautonomia
		Congenital heart block
	OFTALMO
		Uveites
		Esclerites e Epiesclerites
		Vasculites
		Doenças autoimunes da órbita
		Sarcoidose
		Vogt-Koyanagi-Harada
		Retinopatia autoimune
		Neurite óptica
		Ocular cicatricial pemphigoid
		Sympathetic ophthalmia
		Ligneous conjunctivitis
		Pars planitis (peripheral uveitis)
		AZOOR - acute zonal occult outer retinopathy
	MISCELÂNEA
		IgG4-related diseases
Dr. Carlos A von Muhlen: Dr. Carlos A von Muhlen:
Immunoglobulin G4-related disease (IgG4-RD) is characterized by fibrous swelling of affected organs, elevations in serum IgG4 concentrations, and responsiveness to glucocorticoid treatment1​. Affected tissues display similar histological features: diffuse lymphoplasmacytic infiltration by numerous IgG4-positive plasma cells, occasional eosinophils, storiform fibrosis, and obliterative phlebitis2.
		
Dr. Carlos A. von Muhlen: Dr. Carlos A. von Muhlen:
Intern Med. 2016;55(21):3181-3184. Epub 2016 Nov 1.
Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus.
Sekiguchi K1, Yasui N, Kowa H, Kanda F, Toda T.
Author information
Abstract
We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.	
Dr. Carlos A. von Muhlen: Dr. Carlos A. von Muhlen:
Ann Neurol. 2017 Jan 24. doi: 10.1002/ana.24881. [Epub ahead of print]
GFAP-IgG as Biomarker of Autoimmune Astrocytopathy: Analysis of 102 Patients.
Flanagan EP1,2, Hinson SR2, Lennon VA1,2,3, Fang B2, Aksamit AJ1, Morris PP4, Basal E2, Honorat JA2, Alfugham NB1, Linnoila JJ1, Weinshenker BG1,2, Pittock S1,2, McKeon A1,2.
Author information
Abstract
Objective A novel autoimmune CNS disorder with glial fibrillary acidic protein (GFAP)-IgG as biomarker was recently characterized. Here, 102 patients with GFAP-IgG positivity are described. Methods The 102 included patients had: 1) serum, CSF or both that yielded a characteristic astrocytic pattern of mouse tissue immunostaining; 2) confirmation of IgG reactive with specific GFAP isoforms (α, ε, or κ) by cell-based assays, and 3) clinical data available. Control specimens (865) were evaluated by tissue (542) and cell-based (323) assays. Results Median symptom-onset age was 44 years (range, 8-103) and 54% were women. The predominant phenotype (83 patients; 81%) was inflammation of meninges, brain or spinal cord, or all 3 (meningoencephalomyelitis). Among patients, highest specificity for those phenotypes was observed for CSF testing (94%), and highest sensitivity was for the GFAPα isoform (100%). Rare GFAP-IgG positivity was encountered in serum controls by tissue-based assay (0.5%) or cell-based assay (1.5%), and in CSF controls by cell-based assay (0.9%). Among patients, striking perivascular radial enhancement was found on brain MRI in 53%. Though cases frequently mimicked vasculitis, angiography was uniformly negative, and spinal imaging frequently demonstrated longitudinally-extensive myelitic lesions. Diverse neoplasms encountered were found prospectively in 22%. Ovarian teratoma was most common and was predicted best when both NMDA-R-IgG and AQP4-IgG coexisted (71%). Six patients with prolonged follow-up had brisk corticosteroid response, but required additional immune-suppression to overcome steroid-dependency. Interpretation GFAPα-IgG when detected in CSF, is highly specific for an immunotherapy-responsive autoimmune CNS disorder, sometimes with paraneoplastic cause.	Pancreatite autoimune
			Paquimeningite hipertrófica
		Dressler’s syndrome
		Evans syndrome
		POEMS syndrome
		Mooren’s ulcer
		Mucha-Habermann disease
		Restless legs syndrome
		Retroperitoneal fibrosis
		Schmidt syndrome
		Balo disease
		Susac’s syndrome
		Tolosa-Hunt syndrome
		Parry Romberg syndrome
		Parsonnage-Turner syndrome
		Sperm & testicular autoimmunity
		Stiff person syndrome
		Cold agglutinin disease
		Vasculites
		Autoanticorpos associados a câncer
REUMATO
		fator reumatóide IgG / IgA / IgM
		anti-CCP
		FAP
		anti-queratina
		anti-Sa
		MCV (vimentina mutada citrulinada)
Sheet3