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A C K N O W L E D G E M E N T S I am grateful to the Editors of the Biochemical Journal for permission to publish Figs. 3.2,5.3 and 6.11 : to the Editors of Helvetica Chimica Ada and Dr. R. Neher for permission to publish Figs. 3.22 and 3.23 : to the Editors of the Journal of Endocrinology for permission to publish Figs. 3.3 and 4.3 : and to Messrs. J. & A. Churchill, Ltd., London, and Pro- fessor C. J. O. R. Morris for permission to publish Fig. 3.8a. I am also grateful to the following for many useful dis- cussions, and for their generosity in providing unpublished material in advance or for drawing my attention to special features of their publications. Any errors of interpretation are, however, my own responsibility. Dr. W. Acklin, Dr. H. Dowlatabadi, Dr. L. L. Engel, Dr. A. Izzo, Dr. A. T. James, Dr. E. H. Keutmann, Dr. W. Klyne, Dr. M. Lewbart, Dr. S. Lieberman, Dr. A. G. Long, Professor G. F. Marrian, F.R.S., Dr. R. Neher, Dr. R. Peterson, Professor U. Prelog, Professor T. Reichstein, Dr. L. Reineke, Dr. J. J. Schneider, Dr. & Mrs. J. Tait, F.R.S., Dr. P. Vestergaard, Dr. L. I. Woolf, and Dr. A. Zaifaroni.