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Acknowledgments I am deeply grateful to the Almighty God who gave me inspi- ration and courage to conceive the importance of writing this book and accomplish it successfully. My deepest gratitude to all my family members who are my source for love and inspiration. I am thankful to my wife Yasmeen for her motivation and support that kept me resolute in the writing process. I am obliged to thank my sons Abdur Raafay (in A2 level) and Abdul Hadi (in grade 9) who took keen interest in draw- ing some of the chemical structures of the inhibitors discussed in the book. Of course I cannot forget to mention my 5-year old daughter Aaminah whose inquisitive company I used to enjoy while writing the manuscript. Thanks to my colleagues at our unit and department for their good wishes. Thanks to Kelsey Connors, the Editorial Project Manager at Elsevier, Boston, MA, United States, for her excellent coor- dination, follow-up, and patience throughout the project. Thanks to all authors and publishers for permission to reproduce some figures for the book. xvii Acknowledgments