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Solutions for Condensations and Alpha Substitutions of Carbonyl Compounds
CH3
O
O
CH3
O
CH3
O
O
O
O
CH3
O
O
O
CH3
O
O
CH3
O
O
O
O
CH3
O
CH3
O
Michael addition forms a bond to the β' carbon:
α'
β'
α
β
(b) Aldol and dehydration form the α,β double bond:
β'
α'
Michael addition forms a bond to the β' carbon:
β
α
(a) Aldol and dehydration form the α,β double bond:
59 The Robinson annulation consists of a Michael addition followed by aldol cyclization with 
dehydration. In the retrosynthetic direction, disconnect the alkene formed in the aldol/dehydration, then 
disconnect the Michael addition to discover the reactants.
+
+
576