Mapa Metabólico II

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Human Metabolism Glycogen Starch Carbohydrates Bilirubin-diglucuronide Glucose 76 20 1. Main Map Glycosaminoglycans Lactose Maltose Sucrose Phosphoglycerides 114 HSCoA H2O Phosphatidyl-inositol Glycolipids Per Hellung Larsen & Jens Dilling Lundgren & UDP 124 H2O H2O 91 Galactose Gal-1 181 -Bilirubin Lars Helleberg & Mogens Sandbjerg Hansen Lipids Sphingomyelin 117 NADH Glucose- Fructose -Diglyceride Munksgaard 1987 rev. Aug. 2010 UDP-Glucuronate UDP-Gal Mainly in Phosphatidyl-choline Gangliosides A 74 fat cells (Lecithin) Additional 196 ATP serine Phosphatidyl-ethanolamine sugar- Glucose- 151 Glucose-6-P 150 Fructose- 146 residues -P 75 ethanol- Cerebrosides NADPH H2O Purine 149 67 68 Monoglyceride amine GTP Purinnucleotide Glucono-lactone H2O NADH 2'de 5'ATP 11 synthesis ATP CMP 5'AMP 5'IMP Salvage Fructose- -di-P Glyceraldehyde Glycerol UDP Inositol 174 -ATP Pathway CMP 6-P Glycerol NADH Asp+ATP 108 Gluconate Glucose or Not in HSCoA HSCoA galactose 2'de5'ADP AMP Hypoxanthine 152 NADPH Phosphate Dihydrox/ NADH 88 -GTP 5'XMP or guanine Pathway Gly+ATP aldehyde acetone-F Glycerol-3- Lysophosphatidate Phosphatidate CDP-Diacylglycerol CMP 190 DNA Acetylcholine 87 174 PP-2P B -CTP -amine 1,2-Diglyceride CO2 HSCoA 35 N-Acylsphingosine B Ribulose- 5-P C5 Acetate Acetyl-CoA 2P+PP+Glu HSCoA -TTP 2'de5'GDP ATP P-Glycerate Choline P-Choline CDP-Choline TPP 5'CTP 5'CDP 5'CMP -PP Ribose- CTP PP-2F 154 174 AMP 189 187 Sphingosine 157 C3 3-P Ethanolamine P-Ethanolamine CDP-Ethanolamine 62 -ATP Cytosol 53 ATP 132 2'de5 CDP synthesis TPP CTP PP-2F CO2+HSCoA Xylulose 5 Pyridoxal-F Serine 141 NADH -GTP 5'UTP 5'UDP 5'UMP 5'Orotidylate 189 2 RNA Glycerate P-OH-Pyruvate 153 119 174 CO2 Dihydro- Carbamoyl- C5 Pyridoxal- -CTP 142 Palmitoyl-CoA Orotate ATP H2O Glycerate->OH-Pyruvate Glycine 134 178 2'de5'UDP de5'UMP orotate aspartate 178 Linolate NADH Phosphoenolpyruvate Pyridoxal-P Cr-THFA Fatty acids Eicosanoids 176 -UTP H2O Aspartate Pyridoxal-P Cr-THFA (FFA) Linolenate C Aminoacrylate 2 ATP Threonine CO2 C20 C NH2 (Essential unsaturated 2'de5'TDP 172 2'de5'TMP ATP NADPH Aminoacetone 185 Acyl-CoA ACP (de)Nucleotide CO2 Pyruvate NADPH Cysteine Methionine 115 TPP Pyridoxal-P 137 CO2 171a Buturyl-ACP Acyl-AMP 169 12 Phenylalanine Alanine Tyrosine Thyroxine NADPH Lactate HSCoA The names of Cytosol CO2 58 (de) (de) (de) Ethanol NADPH the metabolites refer AMP (de) Pyridoxal-P 148 conversion Transport-protein: Phenylpyruvate Cytosol Biotin TPP Crotonyl-ACP Acyl AdenosineGuanosine Cytidine Thymidine NADH- GTP Carnitine 192 193 171b Lipoamide(ox) 13 NADH cycle events 10 Phenyllactate CO2 Melanin 123 Mitochondria Dopa 100 Mitochondria NH Acetaldehyde (de) (de) Phenylacetate 107 Oxaloacetate FAD NADH 13a -3-Hydroxybutyryl-ACP (60) Enoyl-CoA D Inosine Homogentisate 122 HSCoA FFA-synthesis Uridine FFA-catabolism D Phenyl ketone bodies Dopamine 171c Acetate NADH 59 135 135 (de)Ribose 4-Maleyl- Malate Citrate Only during Acetoacetyl-ACP (102) Hydroxyacyl-CoA Guanine Uracil acetoacetate Hypo- Thymine xanthine Norepinephrine Required the Acetyl-CoA Acetyl-ACP 101 NADH 93 H2O 3,4-Dihydroxy- 4-Fumaryl- Fumarate Cis-Aconitate 5 FFA-synthesis acetoacetate Cofactor: Ketoacyl-CoA 200 Dihydrothymine phenylglycol- Biotin Used during 183 HSCoA aldehyde Epinephrine 179 TCA-cycle cycles Xanthine (Adrenaline) Acetoacetate Succinate Isocitrate Melatonin Malonyl-CoA ACP Propionyl-CoA from N-Carbamoyl- 133 C-uneven FFA yl-CoA H2O+O2 200 ~CH3 HSCoA Cofactors: epinephrine NADH 5-Hydroxy- isobutyrate Catecholamines HSCoA E Urate Pyridoxal-P Succinyl- CoA FAD Oxalosuccinate tryptamine 450 Estradiol Testosterone Estrone Aldosterone Methyl-malonat- Methyl-malonyl- 109 CO2 Testes E Ovary Adrenal CO2+NADH CO2 C18 C19 C21 semialdehyde CoA cortex Acetyl-CoA NH tryptophan Androstendione Corticosterone NADH or Pyridoxal-F Glutamine Asparagine 77 (NADPH) Proteins 81 Histamine Glu+AMP+PP-2P butyrate H2O Tryptophan 1,25-Dihydroxy- P 450 Requires N-acetyl- H2O GluNHz+ATP (GABA) cholecalciferol Pyridoxal-P 17-Hydroxy- 450 glutamate synthesis Lysine Acetoacetyl-CoA Cortison Cortisol progesterone Progesterone Citrulline Aspartate Oxaloacetate Glutamate rANA Histidine Carbamoyl-P Kidney P 450 CO2 C21 Adrenal C21 450 C21 Uterus and 144 139 ATP+NADPH 112 cortex ATP Phenylalanine-Tyrosine corpus luteum H2O Succinate Aminoacyl-t tRNA Mitochondria Ornithine 78 Pyridoxal-F Ketogenic amino acids Pregnenolone AMP+PP-2P F Glutamate semialdehyde isoleucine Succinyl-CoA 25-Hydroxy- AMP NADH 138 Leucine F cholecalciferol 450 15 NADPH Urea synthesis tRNA Cytochromes 118 Liver Aminoacyl-AMP -Ketoglutarate Glutamate Catalase Urea- Cytosol Glycine A Pyrrolin-5-carboxylate Fumarate 450 Dihydroxy- Fumarate Peroxidase Cofactors 15 Pyridoxal-P NADPH TPP Cholecal- UV- 7-Dehydro- cholesterol ATP Hemoglobin Lipoamide light 168 acids acids Arginine Myoglobin HSCoA FAD Isovaleryl-CoA H2O ciferol cholesterol 450 CO2 188 Cobalamin= Proline Squalene Cholesterol Pyridoxal-P General reactions C27 for amino acids Peptide(s) FADH2 Amines -Creatine ATP Heme 106 164 Liver hydroxy-trp-serotonin, glutamate-GABA) Creatine 64 Hydroxyproline ATP Protoporphyrin 126 S-Adenosyl- S-Adenosyl- Cofactor: Trihydroxy- Methionine Biotin Acylglycine Cyclic AMP Creatinine 125 methionine e.g. 34 homocysteine H2O NADPH NADPH ATP Isopentenyl- coprostanoate G Heme (SAM) methyl-glutaryl- Mevalonate p-Methyl-glutaconyl-CoA synthesis Cobalamin= pyrophosphate AMP Guanidinoacetate Coproporphyrinogen Cr-THFA CoA (Cs) Adenosine 104 Cholate ATP ATP 5'AMP CO2 HSCoA Valine Serine C24 Glycine NADPH Uroporphyrinogen H2O ATP Cystine 103 AMP ATP NAD 167 Cystathionine HSCoA 198 Acetone 94 CO H2O NADP FAD Tetrapyrrole 2 (Gly+ATP) NADPH 83 butyrate Cholyl-CoA Cysteine ATP 41 Pyridoxal-P PAPS Isoleucine Threonine Heme catabolism Homoserine Cysteine Glutathione 2 Glutathione Ketone bodies -CO2 Biliverdin (Active sulphate) (red) the liver CO2 ATP 30 H ATP NADPH Porphobilinogen Cofactor: Biotin TPP HSCoA Oxidative phosphorylation Glycine Taurine ATP FMN Bilirubin 18 H Mitochondria ATP ATP ATP HSCoA HSCoA Acetyl-CoA ATP UDP-Glucuronate NADH+H+ FMN Cyt b(+ Cyt Cyt c(+ Cyt a(+2) Cyt a3(+ Cu(+1) 1/2 ATP ATP ATP TPP. Trp Niacin Thiamine Riboflavin Panthothenate Bilirubin-diglucuronide Propionyl-CoA FAD Cu(+2) Glycocholate NAD+ FMNH2 CoQ10 Cyt b(+ 2) Cyt Cyt c(+2) Cyt a(+ Cyt a3(+2) Bile pigments CO2 130 NADH FADH2 2 H+ H2O 1 2 3 4 5 6 7 8 9 11 12